Can weight loss drugs affect your mental health? Experts share insights
GLP-1 receptor agonists (GLP-1 RAs) have long been touted for their ability to help control type 2 diabetes and aid in weight loss. Medications like semaglutides (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda) have been shown to have a significant impact on physical wellness. However, recent studies have raised concerns about the potential effects of these drugs on mental health.
One study published by the National Institutes of Health (NIH) in June 2024 suggested a correlation between semaglutide therapy and mood disturbances, particularly in patients with type 2 diabetes and a history of depression. This led researchers to warn healthcare providers about the possible risks associated with these medications.
On the other hand, a more recent study published in the journal Diabetes, Obesity and Metabolism found that mood changes related to GLP-1 RAs were linked to genetic variations across diverse populations. While the medications had consistent effects on cardiometabolic health, the impact on mental health was more varied, indicating that behavioral changes were likely not directly caused by the drugs themselves.
Dr. Brett Osborn, a neurosurgeon who frequently prescribes GLP-1 RAs, believes that there is no consistent causal relationship between these medications and mental illness. He points out that patients with type 2 diabetes or obesity are often already struggling with depression and anxiety, and the conditions themselves can take a toll on their mental health.
When individuals start to see improvements in their physical health, such as weight loss and stabilized blood sugar levels, their mood often improves as well. Dr. Osborn emphasizes that these medications can help people reclaim their health by reducing inflammation, lowering blood sugar, and improving overall well-being.
Dr. Muhammad Ghanem, a bariatric surgeon, acknowledges that some patients may experience mood changes while taking GLP-1 RAs, but it is difficult to determine whether these changes are directly related to the medications or other factors. He stresses the importance of monitoring patients closely and seeking support from healthcare providers if needed.
Overall, it is essential for individuals taking GLP-1 RAs to pay attention to their mental health and seek help if they notice any concerning symptoms. While these medications can have positive effects on physical wellness, it is crucial to consider the potential impact on mental health and address any issues that may arise.
