Drugs that reduce dementia risk — and others that increase it
A recent study conducted by the universities of Cambridge and Exeter has revealed that some medications may have the unintended benefit of reducing the risk of dementia. The researchers evaluated several existing drugs to see if they could potentially be used as treatments for dementia. The study analyzed data from 14 prior studies, which included over 130 million patients and one million dementia cases.
The findings of the study, published in Alzheimer’s and Dementia: Translational Research & Clinical Interventions, showed that certain classes of prescription drugs were associated with a lower risk of dementia. Antibiotics, antivirals, anticoagulants, anticonvulsants, and certain vaccines were all linked to a reduced risk of developing dementia. This suggests that common dementias may be triggered by viral or bacterial infections, highlighting the potential role of vaccines in reducing dementia risk.
In addition to these medications, anti-inflammatory drugs like ibuprofen were also found to lower the risk of dementia. Inflammation has been implicated in the development of various diseases, including dementia, making anti-inflammatory medications a promising avenue for further research.
On the other hand, some medications were associated with an increased risk of dementia, such as antipsychotic medications. There was conflicting evidence for other classes of drugs, including those used for blood pressure, depression, and diabetes.
While the study provides valuable insights into the potential impact of certain medications on dementia risk, it also has some limitations. Variations in study methodologies and data collection methods can affect the overall quality of the findings. Despite these limitations, the study underscores the importance of conducting comprehensive medication reviews for older adults at risk of dementia.
Dr. Chris Vercammen, a board-certified internal medicine physician at the University of California, San Francisco, emphasized the importance of personalized care for individuals at risk of dementia. He highlighted the need to consult with healthcare providers before making any changes to medication regimens.
Overall, the study sheds light on the potential role of existing medications in reducing dementia risk. While more research is needed to fully understand the impact of these medications, the findings offer hope for future treatments and preventive strategies for dementia. Personalized care and regular medication reviews are crucial in providing comprehensive support for individuals at risk of dementia.
