Hidden dangers of common medications and supplements causing liver damage
Arun Sanyal, M.D., the director of the VCU Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, recently shared exciting news about a breakthrough clinical trial involving 800 participants. The trial focused on the use of a weekly dose of semaglutide, which proved to be effective in treating fatty liver disease. This is a significant development as cases of drug-induced liver injury (DILI) have been on the rise, with experts warning about the hidden dangers associated with some common medications and supplements.
According to recent research published in the journal Toxicology Reports, around one-fifth of the total population prescribed medications will experience DILI. This makes it a significant cause of acute liver failure, especially in Western countries where the incidence has been growing since the 1960s. The study also highlighted potential triggers of liver injury, including herbal products, dietary supplements, and medications. Individuals with pre-existing liver conditions, nutritional deficiencies, and pregnant women are at a higher risk of experiencing DILI.
The liver plays a crucial role in metabolizing substances taken orally, including supplements and medications. However, for some individuals, the process of metabolization can be slow, increasing the risk of liver damage. Even FDA-approved medications can potentially cause liver injury in rare cases. Common symptoms of liver disease include nausea, loss of appetite, abdominal pain, itching, dark urine, and jaundice.
The recent study in Toxicology Reports identified several medications that are most likely to cause liver injury, including paracetamol, NSAIDs, aspirin, corticosteroids, and antibiotics. Additionally, herbal and dietary supplements have also been linked to DILI. Cases of DILI associated with these supplements have nearly tripled between 2004 and 2014. Some of the most commonly implicated botanical products known for potential liver toxicity include turmeric, green tea, ashwagandha, garcinia cambogia, red yeast rice, and black cohosh.
Dr. Marc Siegel, Fox News senior medical analyst, highlighted the risks associated with herbal supplements, noting that the amount of active chemicals in these supplements is not strictly regulated. He cautioned against the potential liver-related risks of popular supplements like turmeric and garcinia cambogia. While turmeric can be useful in small doses, it can be toxic in large amounts. Similarly, garcinia cambogia, often marketed as a weight-loss supplement, lacks evidence of efficacy and may pose risks to liver health.
In conclusion, it is essential to be cautious when using medications and supplements, as they can potentially cause liver injury. The FDA regulates dietary supplement products and ingredients under a different set of regulations than conventional foods and drugs. Manufacturers and distributors are responsible for ensuring the safety and labeling of their products. It is crucial to consult healthcare professionals before starting any new supplement regimen to minimize the risk of liver damage.
