Obesity and stress linked to higher risk of deadly cancer, study finds

Obesity and stress have long been known to have negative impacts on health, but a new study from the University of California Los Angeles (UCLA) has shed light on how these factors can magnify the risk of one of the most aggressive types of cancer. Researchers found that stress-related neurotransmitters and obesity-related hormones can activate CREB, a protein that promotes the growth of cancer cells in the pancreas.

The study, conducted on mice, showed that those who ate a high-fat diet were more likely to develop precancerous lesions in the pancreas. When stress levels were also heightened through social isolation, the lesions grew even more. Interestingly, the risk of stress-related cancer was more pronounced in female mice.

To mitigate these effects, the researchers suggested exploring the use of existing medications to reduce the risk of obesity- and stress-related cancers. Beta-blockers, commonly prescribed for high blood pressure, could potentially help in this regard, as they target beta-adrenergic receptors that play a crucial role in stress-related cancer growth.

Pancreatic cancer is known to be one of the deadliest types of cancer, with a low five-year survival rate. Dr. Robert Den, a radiation oncologist, emphasized the importance of early detection and prevention strategies for this disease, which is often diagnosed at an advanced stage.

Den highlighted the strong connection between the mind and body in cancer development, emphasizing the role of stress and obesity in exacerbating disease progression. He recommended maintaining a heart-healthy diet, exercising regularly, practicing mindfulness, and spending time outdoors to reduce cancer risk and improve overall well-being.

While there have been advancements in chemotherapy and surgical techniques for pancreatic cancer treatment, there is still a need for breakthroughs in immunotherapy. Surgery remains the best line of defense, but finding ways to help patients who are not candidates for surgery poses a significant challenge.

In conclusion, the study underscores the importance of addressing stress and obesity as risk factors for pancreatic cancer. By adopting healthy lifestyle habits and seeking early detection, individuals can potentially reduce their risk of developing this aggressive disease.